Oxygenated Compounds → Ketones → Sesquiterpene ketones (Sesquiterpenones)
Terpene ketones are created through the oxidation of secondary terpene alcohols, featuring a carbonyl or keto group as their functional group.
Formula: 15 C
Ending: -one
Therapeutic properties:
Physical effects: Sesquiterpene ketones are intimately connected to the skin, mucous membranes, and nervous system. They promote strong regeneration of skin, tissues, and cells, aid in wound healing, and have mucolytic (expectorant) properties. While they share similarities with monoterpene ketones, they do not carry the same side effects.
Psychic Effect: Generally, oils that contain sesquiterpene ketones, even in small amounts, can have a gentle calming effect. They bind strongly to GABA receptors, which helps to enhance brain metabolism and leads to an increase in neurotransmitter levels, thereby reducing nerve cell excitability. These ketones function similarly to sedatives but without any adverse effects. Oils rich in sesquiterpene ketones promote tranquility and peace of mind, and like sesquiterpenes, they help to bolster mental stability. Additionally, sesquiterpene ketones possess a pheromone-like quality.
Structure:
Ketones are structurally similar to aldehydes and also contain a carbonyl group. They can be formed by the oxidation of secondary alcohols. Ketones are generally stable compounds and do not readily undergo further oxidation.
Exemples:
Acyclic: 4,8-dimethylnona-3,7-dien-2-one;
Monocyclic: Atlantone, Bisabolone, Elemenone, Germacrone, Turmerone;
Bicyclic: Acorone, Curcumenone, Nootkatone;
Tetrahydrofuran: Davanone.
Properties of Sesquiterpenones
Acorone, found in Acorus calamus (Sweet Flag), is known for its calming and analgesic qualities in aromatherapy. It may help relieve discomfort, elevate mood, and possibly support cognitive function. It may also offer digestive benefits and possess anti-inflammatory properties.
Atlantone, specifically (E)-α-atlantone, is a sesquiterpene compound obtained from the essential oil of Cedrus atlantica, which is known for its diverse biological effects. In aromatherapy, this compound and the source essential oil are recognized for their anti-inflammatory, analgesic, and immunomodulatory benefits. In addition, they are believed to support respiratory health by aiding in cleansing and decongesting.
Bisabolone, especially in its alpha-bisabolone form, has demonstrated remarkable abilities to reduce inflammation and accelerate wound healing. It possesses both antibacterial and antifungal properties. In addition, it is known for its calming properties and mild hypotensive effects. In addition, alpha-bisabolene is rich in antioxidants, which protect against cellular damage. Furthermore, bisabolene may provide analgesic (pain-relieving), antispasmodic, and antiseptic benefits.
Curcumenone, a compound present in the essential oils of Curcuma species such as turmeric, has demonstrated various potential benefits in aromatherapy, including anti-inflammatory, antioxidant, and antimicrobial properties. These effects are linked to the compound's capacity to engage with different biological systems, which may enhance well-being and health.
Davanone, a key component of davana essential oil, is recognized for its fragrant qualities and possible health benefits. It is believed to play a role in davana’s ability to stabilize mood, promote calm, and provide calming effects. Additionally, davanone is associated with potential anti-inflammatory and antiseptic properties.
Elemenone is known for its floral scent, which can help create a calming and soothing environment in aromatherapy, helping to reduce stress and create relaxation. Additionally, some research indicates that elemenone may have anti-inflammatory, antioxidant, and antimicrobial benefits.
Germacrone, the main ingredient found in Zingiberaceae family, is recognized for its wide range of biological activities, including antitumor, anti-inflammatory, anticancer, antiviral effects, and its ability to modulate the immune system.
Nootkatone is a natural substance found in grapefruit and various other plants. It is prized in aromatherapy for its refreshing, citrusy scent reminiscent of grapefruit, as well as its possible therapeutic benefits. This compound is used in perfumes and can also be included in products designed for aromatherapy, insecticides, and even beauty products intended to treat oily skin.
Turmerone, a compound found in Turmeric, has been shown to exhibit a number of biological effects, such as anti-inflammatory, antioxidant, and anticancer benefits. It is also known for its antimicrobial, insecticidal, larvicidal, and antivenom properties, along with possible immunostimulatory and antitumor effects. In addition, turmerone may promote neuronal development.
Vetivone, which includes both alpha and beta forms, is a sesquiterpenoid compound found primarily in Vetiver (Vetiveria zizanioides) and is prized for its unique aroma. Alpha-Vetivone is noted for its calming, anti-inflammatory, and various therapeutic benefits, while beta-vetivone exhibits antimicrobial, anti-inflammatory, and insect repellent properties.
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